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The anti-inflammatory and cognitive role

of N-Palmitoylethanolamide (PEA)

OVERVIEW

PEA is a non-endocannabinoid lipid mediator that has been incredibly well studied and used in humans for its analgesic-pain management and anti-neuroinflammatory properties. It has been demonstrated to have a high safety and tolerability profile, especially in its micronized form [1]. PEA biological effects are driven by multiple mechanisms of action, mainly interacting with the Central Nervous System (CNS) [1].

Much evidence has shown that PEA ameliorates cognitive impairments, by reducing oxidative stress during loss of neuronal activity, and enhancing neuronal survival. For instance, PEA is the key therapeutical agent to improve cognitive performance in Alzheimer´s Disease (AD) [1], inner retinal function in Glaucoma disease [2], or to reduce chronic pain in the elderly [3].

As already mentioned, PEA is most well-known for its effects on pain and neuro-inflammation [1]. PEA acts as a ligand on PPAR-α receptors, which ultimately leads to the inhibition of NFκβ transcription factor and its proinflammatory pathway. Overall, PEA supplementation promotes a positive effect on cognitive function. These cognitive effects may even extend into promoting feelings of well-being and brain wellness.

PEA HELPS TO MAINTAIN A HEALTHY BRAIN, COGNITIVE AND PAIN STATUS

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Pain

Management

Immune

Function

Cardiovascular

Function

Balanced

Inflammation

Levels

Cognitive  Function

PEA

REFERENCES

1) Beggiato S, Tomasini MC and Ferraro L (2019) Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer’s Disease. Front. Pharmacol. 10:821. doi: 10.3389/fphar.2019.00821.https://doi.org/10.3389/fphar.2019.00821

2) Rossi, G., Scudeller, L., Lumini, C., Bettio, F., Picasso, E., Ruberto, G., Briola, A., Mirabile, A., Paviglianiti, A., Pasinetti, G. M., & Bianchi, P. E. (2020). Effect of palmitoylethanolamide on inner retinal function in glaucoma: a randomized, single blind, crossover, clinical trial by pattern-electroretinogram. Scientific reports, 10(1), 10468. https://doi.org/10.1038/s41598-020-67527-z

3) Paladini, A., Fusco, M., Coaccioli, S., Skaper, S. D., & Varrassi, G. (2015). Chronic Pain in the Elderly: The Case for New Therapeutic Strategies. Pain physician, 18(5), E863–E876 https://nootropicsdepot.com/articles/palmitoylethanolamide-and-its-pain-management-benefits/