Β-Hydroxy-β-Methylbutyrate (HMB) as a muscle regenerator in medical nutrition

OVERVIEW

There are multiple diseases, such as Amyotrophic Lateral Sclerosis (ALS), COVID19 or cancer, which lead to an important loss of mitochondrial function and muscle weakness. There is a new therapeutic trend aimed to increase ATP levels and muscular gain for the recovery of bed-resting patients (1). HMB Oral Nutritional Supplements (ONS) (2) has demonstrated the help to complete this whole muscle fiber formation, strength and energy boost process needed especially during hospital rehabilitation and recovery (1). It is faster and better with HMB to rebuild the muscle activity and reduce fatigue.

WHY HMB?

MALNUTRITION

IMMOBILITY

AGING

MUSCLE LOSS

HMB

MUSCLE GAIN • MUSCLE STRENGTH

MUSCLE FUNCTION

The importance of this active ingredient is not only focused on the preservation of the muscle mass loss, but also avoiding the other secondary negative outcomes if not treated: metabolic disorders, disability… (2).

Also known that in combination with other bioactive ingredients, like Cytidine, Uridine, EAAs and principally Inosine, HMB can synergically produce a beneficial effect for the patients which are losing mobility and muscle volume (2).

Just to keep in mind… HAVE HMB TO ENHANCE LIFE QUALITY OF THE PATIENTS WITH DISEASES CAUSING MUSCLE LOSS AND FUNCTION, LIKE ALS, CANCER AND COVID.

PRINCIPAL CAUSES AND NEGATIVE OUTCOMES IN MUSCLES MASS AND FUNCTION LOSS [2].

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REFERENCES

1) Deutz NE, Pereira SL, Hays NP, et al. Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clin Nutr. 2013;32(5):704-712. doi:10.1016/j.clnu.2013.02.011

2) Sanz-Paris, A., Camprubi-Robles, M., Lopez-Pedrosa, J. M., Pereira, S. L., Rueda, R., Ballesteros-Pomar, M. D., Garcia Almeida, J. M., & Cruz-Jentoft, A. J. (2018). Role of Oral Nutritional Supplements Enriched with β-Hydroxy-β-Methylbutyrate in Maintaining Muscle Function and Improving Clinical Outcomes in Various Clinical Settings. The journal of nutrition, health & aging, 22(6), 664–675. https://doi.org/10.1007/s12603-018-0995-7