COVID-19 & Melatonin:

New vision.

The outbreak of Covid-19 has certainly contributed to increased stress and anxiety levels in the population. Recommendations such as isolation or social distancing increase fear, worry and depression which further contribute to sleep disorders and deterioration of mental health.

 

MELATONIN: A LIGHT AT THE END OF THE TUNNEL?

Melatonin is not only responsible for controlling circadian rhythms and regulating sleep quality, but is also critical to maintain a healthy immune system, essential to fight Covid-19.

 

Melatonin has emerged as a potential coadjuvant fighting Covid-19:

 

  • Attenuates and regulates proinflammatory cytokine levels, preventing the cytokine storm, innate immune system overactivation and acute lung injury (ALI).

 

  • Dampens oxidative stress caused by infection which may cause multiple-organ damage, and also lead to ALI / ARDS (Acute Respiratory Distress Syndrome).

  • Inhibits NLRP3 inflammasome, the main component of the innate immune system with a critical role in inflammation related to lung infections.

  • Has a high safety profile, even at higher doses, melatonin is not dangerous.

NATURAL MELATONIN: AN ADVANTAGE?

The outbreak of Covid-19 has certainly contributed to increased stress and anxiety levels in the population. Recommendations such as isolation or social distancing increase fear, worry and depression which further contribute to sleep disorders and deterioration of mental health.

  • 100% plant extract as opposed to animal or chemical origin

  • Vegan, and conventional / organic grade available

  • Highly stable, for up to 3 years

  • Pure, no additives, chemicals or excipients added

 

Melatonin has a high safety profile and acts as a potent antioxidant and as an immune regulator, controlling the excessive innate pro-inflammatory response and shifting to a more adaptive immune response.

Tan D. et al (2020) Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response

and destructive inflammation: focus on COVID-19. Melatonin Research 3: 120-143

Zhang R. et al (2020) COVID-19: Melatonin as a potential adjuvant treatment. Life Sciences 250: 117583

Zhou Y. et al (2020) Network-based drug repurposing for novel coronavirus 2019-nCOV/SARS-CoV-2. Cell Discovery 6:14

 

 

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